Supply Chain Management (SCM) is a set of approaches tied up to integrate various stake holders along the supply chain namely, suppliers, manufacturers, warehouses, distributors, retailers, customers and all others who are adding value in fulfilling the customer requirements. SCM has gained enormous amount of importance among the participating companies and have realized it as an inevitable mode to achieve competitive advantage. In this paper we have developed mixed integer programming model for multi-vendor multi buyer supply chain problem with perishable products. The objective is to determine a periodic policy of production, supply and transportation that minimizing the sum of the inventory and transportation costs. A numerical case study is elucidated to demonstrate the salient features of the proposed model.