Innovative and entrepreneurial skill acquisition in Nigeria entails focusing on what should be done to bridge the gap between the school and labor market, where the learner will work after graduation, so as to be self-reliant in the society. Specifically, the study seeks to be determined: The innovative and entrepreneurial skills needed in basic science education for job creation and the teaching strategies required. The study was carried out in Rivers State and was guided by two research questions (RQs). A descriptive survey research design was adopted. The population of the study was made up of 150 principals and 250 basic science teachers. While the Sample consist of 100 science teachers and 50 Principals. The instrument used for data collection was a 20-item questionnaire. Mean and standard deviation statistics were used to address the two RQs. The findings revealed that a lot of skills were needed in Basic Science for job creation, the teachers were required to use practically oriented methods in teaching the students.