Predictions is a strategy in which readers use information from a text (including titles, headings, pictures, or diagrams) and their own personal experiences to make a good prediction before reading, while reading, and after reading. This research is a true experimental study that entails random technique sampling. The research aimed at answering the questions whether or not prediction strategy may improve students’ ability in reading comprehension. This study involved tenth grade students of SMAN 1 Pulau Morotai. Random sampling method was applied, with 30 students. The result of this study showed that the score in experimental class which was taught by using prediction strategy was higher (46.3 to 71.9) than those of the control class which was taught without prediction strategy (46.06 to 49.33). In addition, based on the analysis the result of the questionnaire, most of the students gave positive response to prediction strategy. It could be concluded that prediction strategy is considered effective in improving students’ reading comprehension.