This study is an attempt to explore the effect of stress and Profession on job satisfaction. Moreover it is also to study the effect of independent variables i.e. Stress and Profession on dependent variable i.e. job satisfaction. In order to study, 270subjects were taken including 90 doctors, 90 teachers and 90 advocates. F-test and New-man kaul test were also administered. The results show that Stress and Profession effect job satisfaction.