The Kenyan government committed itself in the first Medium Term Plan 2008-2012 of Vision 2030, to improve and modernize Kenya’s infrastructure to world-class in order for the country to achieve middle-income status and enhance welfare of her citizens. In Kenya, the number of poor people increased substantially over the ten-year period 1999-2009. Given this scenario, an explanation of this requires studying the influence of economic infrastructure development on household well-being among small holder farmers in Butere Sub-county. The specific objective of the study was to investigate the influence of road infrastructure on household well-being among small holder farmers in Butere Sub-county. The study adopted descriptive research design, which ensured ease in understanding the insight about the problem under study. Primary data from a sample of smallholder farmers within Butere Sub-county making a total of 2,183 formed the target population. A sample size of 339 respondents was used to represent the target population. A self-administered questionnaire was used for data collection since this can be send to a large number of people. The collected data was analysed using inferential as well as descriptive statistics. The study findings showed a significant relationship between road infrastructure and household well-being of smallholder farmers in Butere Sub-county. The study recommended that the Kenyan government need to ensure dedicated institutions and enabling policy and regulatory frameworks to make sure relevant institutions such as Kenya Rural Roads Authority is strengthened, with a clear mandate, authority and resources to fulfil the mandate, and accountability for achieving that mandate.