A randomized control study was conducted to assess the effectiveness of self-instructional module on knowledge of self-management among patients undergoing hemodialysis in tertiary care Hospital, using simple random technique method. Data was collected. Then SIM was administered in experimental group. The obtained data was analyzed by using frequency, percentage, mean and standard Deviation. The study findings revealed that there is much gain in knowledge of self-care management among CKD patients undergoing Hemodialysis in posttest of experimental study. So the SIM was an effective to enhance the Knowledge of self-care management.