The antimicrobial potential of guava (Psidium guajava) leaf extracts against two gram- negative bacteria (Escherichia coli and Salmonella enteritidis) and two gram-positives bacteria (Staphylococcus aureus and Bacillus Cereus) which are some of food borne and spoilage bacteria. The guava leaves were extracted in four different solvents of increasing polarities (hexane, methanol, ethanol and water). The guava (Psidium guajava) is a Phytotherapic plant used in folk medicine that is believed to have active components that help to treat and manage various diseases. The challenges in organic synthesis are develop convenient process. Reaction media conditions and utility of material based on the design of green chemistry is one of the important issues in the chemical society in resent strong synthesis effort.