The present study was mainly focused on in-vitro thrombolytic and anti inflammatory activity of petroleum ether, toluene and methanolic extracts of Cipadessa baccifera petroleum ether and methanolic extracts of Elytraria acaulis. The extracts of Cipadessa baccifera showed 54.64% of clot lysis and the Elytraria acaulis exhibited the maximum 66.53% of clot lysis. The result findings indicated that concentrations of leaf extract enhanced the percentage of clot lysis in dose dependent manner along with the incubation time factor. However; streptokinase SK a reference standard and water were used as a positive and negative control showed clot lysis maximum 79.86% respectively. During this study petroleum ether and methanolic extracts of Elytraria acaulis showed the inhibition of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti inflammatory activity. The percentage of membrane stabilisation for petroleum ether and methanolic extracts and Diclofenac sodium were done at different concentrations. The maximum membrane stabilization showed in the methanolic extract and petroleum ether extract of Elytraria acaulis extracts was found to be 57.14% and 44.89% at a dose of 60 mg/ml. Therefore, our studies support the isolation and the use of active constituents from Elytraria acaulis in treating inflammations. But in case of Cipadessa baccifera did not showed the inhibition of hypotonicity induced HRBC membrane lysis. As a result Cipadessa baccifera did not take part in anti-inflammatory activity.