Background: Musculoskeletal disorders (MSD) comprise significant occupational injuries and disability within the nursing profession, This study found a high prevalence of LBP, Shoulder, neck and Knee pain over a 12-month period among nurses working in hospital, and certain risk factors like working in same position for long time, bending, twisting, lifting and treating excessive number of patients were strongly associated with WMSDs. Objective:To determine the effectiveness of workstation exercises with ergonomic intervention to reduce pain and disability among nurses. Materials: 1. Inch tape, 2. Goniometer Methodology: 50 individual nurses with musculoskeletal disorder will be selected based on inclusion and exclusion criteria. Detailed procedure will be explained in patient’s words and informed consent will be obtained from all the participants. Subjects will be assessed for presence of musculoskeletal disorders affecting various body regions. The participants asked to fill the questionnaires form about musculoskeletal symptoms and intensity or severity of pain experienced. Pain will be measured in Numerical pain rating scale (NPRS) and disability Cornell musculoskeletal discomfort questionnaires. The post test value will be taken after two weeks. Outcome Measures: 1. Numerical Pain Rating Scale, 2. Cornell Musculoskeletal Discomfort Questionnaire. Results: From statistical analysis made with quantitative data revealed extremely statistically significant. The post test mean value for numerical pain rating scale (NPRS) is P is less than 0.0001.The post test value for Cornell musculoskeletal discomfort questionnaire scale (CDMQ) is P is less than 0.0001.Statistical analysis of post test, Numerical pain rating scale (NPRS) and Cornell musculoskeletal discomfort questionnaire revealed that there is extermely statistically significant Conclusion: The study concluded that studies involving ergonomics will be of importance in identifying prevention strategies. Ergonomic training on proper lifting and transfer techniques, body awareness, and reduction in workload may be helpful for nurses.