The present study shows the anthelmintic activity of Clerodin, extracted from Clerodendrum infortunatum leaves against the Pheretima posthuma (P. posthuma).We tried to inhibit the growth of P. posthuma. Extracted Clerodin of C. infortunatum leaves were investigated for its anthelmintic activity against the P. posthuma. Salkowski test indicated the presence of clerodin in the hexane extract. Piperazine citrate was used as standard. The Clerodin showed Paralysis time and Death time 4.84 minutes and 9.37 minutes respectively at the concentration of 30 mg/ml, but Piperazine citrate showed paralysis time and death time 7.87 minutes and 13.32 minutes respectively at the same concentration. Overall experimental result revealed that Clerodin has higher anthelmintic activity than natural inhibitor of P. posthuma, Piperazine citrate.