The objective of this study is to examine the determinant of household food security in Southern part of Tigray Regional State, Northern Ethiopia. To achieve this objective, both primary and secondary sources were employed to collect the data for the study area. Descriptive statistics and logistic regression model were used to analyze the determinant of household food security in the study area. The results show that livestock ownership, land holding size, age of head, amount of rain fall, concrete river diversion and deep well irrigation were robust and positively influence food security while family size had a negative effect.