The present investigation was carried out to find out the changes in enzyme activities during vermicomposting which offers a promising solution for assessment of quality of vermicompost. The different bio-degradable wastes (agricultural wastes, kitchen wastes, vegetable market wastes and paddy straw) were composted separately using earthworms. The results revealed that initial enzyme activity (urease, acid, alkaline phosphatase and dehydrogenase) was high. With time, enzyme activity decreased as availability of organic compounds decreased. Highest enzyme activity was recorded with vermicompost prepared out of agricultural wastes while least with paddy straw.