Tulsi “Queen of herbs” is described as sacred and medicinal plant in ancient literature. It is an important symbol of the Hindu religious tradition. The name Tulsi is derived from “Sanskrit”, which means “matchless one”. Its other name, Vishnupriya means the one that pleases Lord Vishnu. This plant (Ocimum sanctum) belongs to the family Labiatae, characterized by square stem and specific aroma. This review has been conducted to pile up information that is available in different scientific literatures and this update compendium documentation has focused on some of the antibacterial aspects and phytochemical constituents. From the result it reveals that wide numbers of phytochemical constituents have been isolated from the plant as cirsilineol, circimaritin, isothymusin, apigenin and rosameric acid, and appreciable quantities of eugenol and is proved to have potential for medical effects as antimicrobial, anti-inflammatory, and antifungal activity. The antibacterial effects of O. sanctum may delay the development some life threating complications and this work stimulates the researchers for further research on the potential use of this medicinal plants having pharmaceutical potential.