The Serlui River is one of the important rivers in Kolasib, Mizoram. The present investigation was carried out for a period of two years (March 2015- February 2017) to study the water quality of Serlui River in vicinity of Serlui-B hydel project using statistical tools for significance and validity of findings. Altogether, three sampling sites were selected from upstream to downstream of river along the hydel project. The water samples were collected at monthly interval water quality attributes namely, pH, Acidity, Total Alkalinity, Dissolved Oxygen and Biological Oxygen Demand were analyzed following the standard methods. A correlation matrix test (p<0.05) and linear regression analysis were computed to check the significant relationship between the water quality parameters. The finding reveal that the values were within the prescribed limits given by various scientific agencies, but intensity of pollutants increased from Site 1 (Control Site) to Site 3 (Downstream), indicating impact of hydel project on river water quality. From the statistical analysis, a highly positive and significant correlation was observed between pH and DO (r=0.940, p<0.01), Acidity and BOD (r=0.733, p<0.05), whereas, a highly negative and significant correlation was recorded between pH and Acidity (r=-0.841, p<0.01), pH and BOD (r=-0.938, p<0.01), Acidity and DO (r=-0.764, p<0.05), DO and BOD (r=-0.950, p<0.01). Total alkalinity showed a moderate correlation with pH (r=-0.619), Acidity (r=-0.543), and BOD (r=-0.642) and a weak correlation with DO (r=-0.472).The findings reveal that methodical calculation of correlation coefficient and regression analysis proved to be a convenient mean for rapid monitoring of the water quality of Serlui river.