A field experiment entitled “Integrated Weed Management in Soybean Wheat sequence cropping” was conducted at College of Agriculture, Loni farm during kharif 2015 and kharif 2016 on silty clay loam soil with 7.4 P^H. The climatic conditions during experimental period was favorable. The experiment was laid out in split plot design with three replications. The treatments were consisting of combination of pre and post emergence herbicides, cultural treatments as well as unweed check. The results revealed that the growth parameters, yield attributes, seed yield and straw yield were increased significantly by treatment 1 hoeing at 15 DAS and 2 hand weeding at 20 DAS and 45 DAS over rest of the treatments however it was at par with treatment pendimethalin 30 percent CS (PE) fb 1 HW 30 DAS, meteribuzin 70 percent WP (PE) fb 1 HW 30 DAS and meteribuzin 70 percent WP (PE) fb quizalofop ethyl 5 percent EC (POE) which was followed by treatment metribuzin 70 percent WP (PE) fb imazethapyr 10 percent SL (POE) and pendimethalin 30 percent CS (PE) fb quizalofop ethyl 5 percent EC (POE). The B: C ratio and net returns were found significantly higher in meteribuzin 70 percent WP (PE) fb 1 HW 30 DAS. Significantly minimum growth, yield attributes, yield and economics were noticed in treatment unweeded control for both the years.