Discovery of new chemical entities as efficient and non-toxic chemotherapeutic agents is the only way to overcome the challenging problems of infectious microbial diseases which exist due to emergence of multi-resistant microbial pathogens. Synthetic flexibilities and the chemotherapeutic value associated with hydrazones make itself a privileged pharmacophore in the field of medicine. In order to pave the way for future advanced research, there is a urgent need to collect and analyze the most recent information existing so far in this promising area. This review collected the recent literature reports specifically on antimicrobial potential of hydrazone derivatives which may helpful for the researcher in the field of new drug discovery and development.