Faculty engagement and job satisfaction are essential to achieve the missions of academic medical centers (AMCs). This study investigated whether an “Economics of Clinical Operations” (ECO) course, designed to improve faculty understanding of institutional finances, had a positive impact on the attendees’ perceptions of their career. This study compared questionnaire results of 102 faculty attendees who attended a course on institutional/individual practice finances and 102 matched controls to assess the course’s impact on attendees’ perceptions of their career after 3-18 months. Attendees reported improvement in practice efficiency (95.5% vs. 73.4%), practice profitability (95.2% vs. 56.2%), job satisfaction (86.3% vs. 55.6%), retention likelihood (80.5% vs. 58.5%), feeling supported (81.1% vs. 49.1%), and productivity (97.5% vs. 80.4%) compared with controls (all p < 0.05). Educating faculty on personal / institutional finances can not only improve financial performance but enhance faculty members’ impressions of career satisfaction, institutional support and productivity.