The study was designed to compare the balance between lipid peroxidation and antioxidant enzyme activity in Type 2 diabetes neuropathy patients. The result was compared with the healthy control in the same population. Diabetic neuropathy (DN) patients had higher antioxidant and malondialdehyde (MDA) level than control subject. The study was conducted in the out patients department of endocrinology VIMS, Ramakrishna Mission Seva Pratishthan, Kolkata. The study involved 68 individuals, of which 38 patients with type 2 diabetic neuropathy (confirmed positive sensory/polyneuropathy problem by nerve conduction velocity test) and 30 individual without a history of diabetes as a control group. All procedure was done with the consent of participants. The result showed a positive correlation between superoxide dismutase (SOD) and lipid peroxides (LP) level in diabetic neuropathy patients. These data suggests that MDA, as a lipid peroxides indicator, is higher in diabetic neuropathy patients probably due to chronic high blood sugar followed by higher oxidative stress. It has also been suggested that increased SOD level in diabetic neuropathy (DN) group appeared as a result of protective and adaptive mechanism developed against oxidative stress i.e. free radical generation due to hyperglycemia.