The paper presents an effect of Lead (Heavy metal) on growth characteristics and accumulated content Lead by yeast Saccharomyces cerevisiae. The review of literature on effect of heavy metals on living organisms gives the information about their toxicity and reduction in growth of organism. Lead is a common heavy metal and mankind has known its utility for centuries. It shows toxic effects when accumulated by organism. Saccharomyces cerevisiae is selected for experiment as it is easy to grow in normal laboratory conditions. The study may predict the use of S. cerevisiaein controlling metal ion concentration in the environment.