Topical therapies present a valuable therapeutic option for Osteoarthritis, Rheumatoid arthritis & ankylosing spondylitis pain management including several other inflammatory diseases. In context with topical application of a drug, critical barrier of epidermal membranes offer several diffusional resistance in the course of skin permeation. Thus, the developments of topical products which allow penetration of compounds into the skin require utilization of several approaches. Chlorhexidine is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms, facultative anaerobes, aerobes and yeast. It is used as a topical anti-infective for skin, mucous membranes and as preservative for eye drops. Chlorhexidine is also used as an antiseptic ingredient used in mouth wash to prevent oral plaque, oral bacteria and in treating gingivitis. For the preparation of the gel formulation succinyl chitosan was used as gelling agent. Chlorhexidine gluconate is biguanide derivative having wide spectrum of antibacterial activity. It is highly effective against S. aureus and P. aeruginosa which are responsible for the development of infection in bedsore. Globally bedsore is a major problem in bedridden, old and debilitated patients. Incidence rates in hospitalized patients vary from 0–65.6% in USA and Canada and 2.2–60% in UK. The prevalence of pressure ulcers is 3–11% in hospitalized patients 2.5–24% in nursing-home patients and 17% in adults in community. Chlorhexidine gluconate is highly effective at pH 5-7.5 which is generally a pH of skin.