This article outlines the course of gestation against the background of infections (HSV, CMV, chlamydia, toxoplasmosis) and their consequences and impact on women of childbearing age and the fetus. Types of infections, such as HSV, CMV, chlamydia, toxoplasmosis, were studied on the basis of traditional and modern methods of research, including clinical, biochemical, molecular - biological (PCR), functional, morphological analyzes, and improved tactics of pregnancy management in women in a group of high-risk hazards. Also, topical issues of managing and treating problem pregnancies related to infections (HSV, CMV, chlamydia, toxoplasmosis) in the pre - graft period, and their preparation for childbirth, as well as obstetric tactics on them are highlighted.