Objectives: The aim of the present study was to explore the relationship of perceived social support (support from family, support from friends and support from significant others) and meaning in life (presence of meaning in life and search for meaning in life) with fatalism (Mental adjustment) among cancer patients. The integrative effect of perceived social support and meaning in life on fatalism was also investigated. Method: The sample of the study consisted of 200 cancer patients who were selected on purposive basis from Shri Maharaja Hari Singh Hospital, Srinagar, J&K and Jawahar Lal Nehru Medical College, Aligarh, Uttar Pradesh. The tools used for the present study were Meaning in Life Questionnaire (MLQ) developed by Steger, et al., (2006); Multidimensional Scale of Perceived Social Support scale (MSPSS) developed by Zimet, et al., (1988), and The Mental Adjustment to Cancer Scale developed by (Watson et al., 1988). The data collected was analyzed by using appropriate statistical techniques like Pearson’s product moment correlation and stepwise multiple regression analysis. Results: The results showed significant positive correlation between support from family and fatalism (r=.354, p>.001); support from friends and fatalism (.229 p>.001); support from significant others and fatalism (r=.318, p>.001); overall perceived social support and fatalism (r=.416, p>.001); meaning in life and fatalism (r=.274, p>.001) and between presence of meaning in life and fatalism (r=.426, p>.001). However, there was a significant negative correlation between search for meaning in life and fatalism (r=-.241 p>.001) among cancer patients. Hierarchical regression analyses indicated that social support and meaning in life as a whole accounted for 22.9% variance of fatalism. Conclusion: The findings of the study revealed that perceived social support and meaning in life have a significant positive correlation with fatalism. The largest Beta value (in the 3rd model) of presence of meaning in life (b=.283, t= 3.779, p<.0001) suggests that it made the strongest unique contribution in explaining fatalism and; the Beta value of total perceived social support was slightly lower (b=. 261, t= 3.439, p<.001) which suggests that it made less of a contribution. On the basis of the significance level of the standardized beta value, it can be concluded that perceived social support and presence of meaning in life made a unique and statistically significant contribution to the prediction of fatalism among cancer patients.