This paper is based on impact of industrialization on changes in agricultural practices and dependence of farmers on polluted water for irrigation purpose. Main focus area was Jodhpur and its surroundings. More than 27000 industrial units are working in this area. Among these many units dispose waste material directly into water resources through sewage line or on land. In Jodhpur, Jojari river is most important river for agricultural land. Presently it is polluted with effluent mixed sewage water. Many animals and plants suffer from this unhygienic and hazardous conditions and even some die. Farmers are also using this polluted riverine water for their agricultural irrigation because it is easy and chiefly available. This type of changing pattern of farmer’s irrigation practices may cause major health risk issues in near future for whole population.