Background of the Study: Care giving has been acknowledged as a basic part of human nature and chief component of close relationship. A number of previous studies reveal a higher rate of depression and anxiety among the caregivers as compared to the general population. Regardless of the researches on caregivers, and particularly on their burden, their psychological well-being is not well known. Although the amount of research might suggest most caregivers are vulnerable of collapse, most cope and seem to cope quite well. The purpose of this study is to find out the level of burden and amount of life satisfaction among the caregivers of the patients of schizophrenia as compared to the caregivers of dementia patients. Material and Method: A total number of 100 care givers 50 of schizophrenia patients and 50 of dementia patients from Jawaharlal Nehru Medical College, Aligarh Muslim University Aligarh were selected as sample of the present study. They were tested using The Satisfaction with Life Scale and Family Burden Interview Schedule. Result and Discussion: There is not much difference in the level of burden and only a slightest difference is found between the level of life satisfaction among the caregivers of schizophrenia and dementia patients.