Banks are the strength and character of the economy of the nation because they engage in recreation noteworthy role in the exertion to attain constant prices, giant level of employment and resonance fiscal growth. The objective of the present study profitability analysis of different public and private sector banks in India based on the performance of profitability ratios like net profit margin, interest spread, return on net worth, return on long term funds and adjusted cash margin. The period of the study is from 2005- 2006 to 2014- 2015. The major finding of study indicates that private sector banks have higher profit than public sector banks during the study period.