Nano-technology, a 21st century technology, became an inevitable ingredient in all walks of life. Industries producing goods for human consumption majorly in various sectors are the main users of the nanotechnology. By virtue of increasing number of inventions in Nano-technology field, the patent offices across the world is filled with applications involving the same. USPTO, EPO and JPO are the main beneficiaries of the upcoming technology. The increasing grant of patents for nanotechnology is the evidence for their effectiveness in catching the upcoming field. Indian patent statistics relevant to nanotechnology is showing poor numbers compared to USPTO, EPO and JPO. This article keenly examines the nano regime in India and comparison of IPO with USPTO, EPO and JPO in grant of nano patents.