The purpose of the present study was to determine the effect of Kalaripayattu training programme on selected Physical variables among inter- collegiate men basketball players. In order to achieve the purpose of the study, thirty basketball players were selected from the affiliated colleges the Kerala university, Thiruvananthapuram. The subjects were randomly selected and their age group ranged from 18-23 years. The selected groups were divided in to two groups, experimental group and control group. The experimental group (EG) underwent the medium of twelve Kalaripayattu selected skill training. The control group (CG) not exposed to any training. Kalaripayattu training is considered as the independent variable. The physical variables (agility, leg explosive power and flexibility) are dependent variables. The statistical technique covariance ANCOVA was used to analyze the pre-test and post-test data of experimental group and control group. The results showed that the Kalaripayattu training group had significant improvement (P ≤ 0.05) in the level of all the selected physical variables as compared to the control group.