The paper presents an effect of Lead (Heavy metal) and Cadmium on growth characteristics and protein content of yeast Saccharomyces cerevisiae. The review of literature on effect of heavy metals on living organisms gives the information about their toxicity and reduction in growth of organism. Lead and Cadmium are common heavy metals and mankind has known utility for centuries. They shows toxic effects when accumulated by organism. Saccharomyces cerevisiae is selected for experiment as it is easy to grow in normal laboratory conditions. The study may predict the use of S. cerevisiae in controlling metal ion concentration in the environment.