The present investigation reveals, the monthly and seasonal variations in concentration of physico-chemical parameters in river Wainganga at Wadsa dist. Gadchiroli. Water samples under investigations were collected from the four different sites during rainy, winter and summer season for the period of one year from July 2014 to June 2015. Wainganga river water was chosen for analysis, because of people’s reliance on the water for their domestic and agricultural use. The present study emphasizes on the magnitude of pollution by monitoring water quality parameters such as water temperature, pH, electrical conductivity (EC), total dissolved solids (TDS), total alkalinity (TA), total hardness (TH),calcium hardness (CaH), magnesium hardness (MgH), dissolved oxygen (DO), chemical oxygen demand (COD), biochemical oxygen demand (BOD), iron (Fe²⁺), chloride (Cl^-), fluoride (F^-), nitrate (NO₃^-), sulphate (SO₄^{- -}), and phosphate (PO₄^3-). The samples of Wainganga river water is assess for physico-chemical parameters and their results are compared with WHO drinking water standards. A correlation matrix test was carried out to check the significant relationship among the physico-chemical parameters (significance level 0.05). Statistical analysis shows that many of the parameters bear a good positive correlation and some bear a negative correlation. Results have shown wide variations from high concentration during rainy season and low concentrations during winter season. Statistical analysis carried out through correlation method and correlation coefficients are calculated between different pairs of parameters to identify the highly correlated and interrelated water quality parameters. The present study indicates that site W₁ and W₂ were comparatively more polluted due to various athropogenic activities taking place at these sites whereas site W₃ and W₄ were comparatively less polluted. It is also been found that the upstream water remains unpolluted, but the downstream water was found to be more polluted.